PROGRAM
Thursday 26 September
18.30 – 20.30
Dinner at De Reehorst for early arrivals
Friday 27 September
08.30 – 09.00
Registration & coffee/tea
09.00 – 09.15
Welcome
Masja de Haas, Leendert Porcelijn and Rick Kapur
Session moderators: James Bussel and Masja de Haas
09.15 – 09.45
FNAIT: is personalized care possible?
Joanne Verweij, Department of Gynecology and Obstetrics, Leiden UMC
09.45 – 10.20
FNAIT: Prophylaxis and tolerance induction from mouse to (wo)men
Maria Therese Ahlen, Department of Platelet Immunology, University Hospital of North Norway, Tromsø
10.20 – 10.45
FNAIT: Integrate the integrins: αVβ3 versus αIIbβ3
Coert Margadant, Institute of Biology, Leiden University
10.45 – 11.15
Coffee/tea break
11.15 – 11.45
FNAIT: place of the placenta
Heidi Tiller, Department of Gynecology and Obstetrics, University Hospital of North Norway, Tromsø. Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø
11.45 – 13.00
Abstracts (5 oral presentations):
11.45 – 12.00
Design of a Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of Nipocalimab in Pregnancies at Risk for Fetal and Neonatal Alloimmune Thrombocytopenia (FREESIA-1)
Heidi Tiller, Department of Gynecology and Obstetrics, University Hospital of North Norway, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø
12.00 – 12.15
Placenta-associated biomarkers and pregnancy outcome in HPA-1a alloimmunization – a prospective cohort study
Nora Hersoug Nedberg, UiT The Arctic University of Norway, Tromsø
12.15 – 12.30
Maternal anti-HPA-1a antibody levels and intracranial haemorrhage in Norwegian FNAIT cohorts
Siw Leiknes Ernstsen, Norwegian National Unit for Platelet Immunology, University Hospital of North Norway, Tromsø
12.30 – 12.45
Rallying the troops: A Delphi Consensus Study on Prenatal Screening and Management in Pregnancies at Risk for Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
Romy Pothof, Leiden University Medical Centre and Sanquin Diagnostics Services Amsterdam
12.45 – 13.00
Design of a Global, Retrospective Chart Review to Characterize the Clinical Course of Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FREESIA-2)
Rebecca Zaha, Janssen Research and Development, LLC
13.00 – 14.15
Lunch
13.30 – 14.15
Breakout Session:
UK NEQAS for H&I External Proficiency Testing for Platelet Services: Current Performance and Future Challenges
Session moderators: Brian Curtis and Leendert Porcelijn
14.15 – 14.45
TRALI: through the eyes of clinicians
Robert Klanderman, Department of Laboratory of Experimental Intensive Care and Anesthesiology, and Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam
14.45 – 15.15
TRALI: new insights into the immunopathology
Rick Kapur, Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam
15.15 – 16.00
Abstracts (3 oral presentations):
15.15 – 15.30
Anti-neutrophil Autoantibodies Are Associated With but Not Required for Triggering Macrophage Uptake of Neutrophils in Vitro by Autoimmune Neutropenia Plasmas
Peter Norris, Karolinska Institutet and Karolinska University Hospital
15.30 – 15.45
Presence of “ACKR1/DARC null” polymorphism in Arabs from Jisr az-Zarqa with benign ethnic neutropenia
Nechama Sharon, Laniado Hospital
15.45 – 16.00
Neonatal alloimmune neutropenia caused by anti-HNA-2 antibodies as a differential diagnosis to congenital neutropenia
Petter Höglund, Karolinska Institutet and Karolinska University Hospital
16.00 – 16.30
Coffee/tea break
Session moderators: Primoz Rozman and Rick Kapur
16.30 – 17.00
Extracellular vesicles: the methodological approach is key
Rienk Nieuwland, Amsterdam Vesicle Center, Amsterdam University Medical Centers
17.00 – 17.30
Extracellular vesicles: influencers of the immune system
Eric Boilard, Department of Microbiology and Immunology, Faculty of Medicine, Université Laval
17.30 – 18.30
Poster walk
18.30 – 21.00
Dinner at De Reehorst
Saturday 28 September
08.30 – 09.00
Coffee/tea
Session moderators: Maria Therese Ahlen and Rick Kapur
09.00 – 09.20
ITP: through the eyes of clinicians
Tanja Netelenbos, Department of Haematology, HagaZiekenhuis Den Haag
09.20 – 09.40
ITP: autoantibody detection
Leendert Porcelijn, Sanquin Diagnostic Services, Amsterdam
09.40 – 10.10
ITP: targeted treatment; what are the current options?
A.J. Gerard Jansen, Department of Haematology, Erasmus Medical Center, Rotterdam
10.10 – 10.40
ITP: T-cells in the spleen
Sylvain Audia, Unit of Tumor-Graft-Versus-Host Interaction / Cellular and Gene Engineering, French Institute of Health and Medical Research
10.40 – 11.15
Coffee/tea break
11.15 – 13.15
Abstracts (8 oral presentations):
11.15 – 11.30
Cutaneous Hemorrhage Types as Supportive Factors for Predicting Chronic Immune Thrombocytopenia in Children
Nechama Sharon, Laniado Hospital
11.30 – 11.45
The ‘Stop TPO-receptor agonist in ITP Patients’ (STIP) study; a quest to unravel the immune modulating effects of romiplostim
Vivianne Nelson, Sanquin/ HagaZiekenhuis/ LUMC
11.45 – 12.00
Isolation and characterization of anti-HPA-1a monoclonal antibodies
Janita Oosterhoff, Sanquin
12.00 – 12.15
An Optimised Procedure for Luminex-based HPA-specific Antibody Screening and Identification (PakLx assay), with a Cost-effective Approach and Improved Sensitivity
Gerald Bertrand, BloodCenter of Brittany EFS
12.15 – 12.30
Performing fetal platelet genotyping on maternal plasma is not necessary in all indications. First retrospective study of French practices and neonate characteristics
Rachel Petermann, APHP – Saint Antoine Hospital
12.30 – 12.45
An accurate determination of HNA-2 with nanopore sequencing
Kirstine Kløve-Mogensen, Department of Clinical Immunology, Aalborg University Hospital
12.45 – 13.00
Autoantibody detection in childhood neutropenia. Do we
need test cells? To bead or not to bead, that is the question!
Paul Ratcliffe, Karolinska Institutet and Karolinska University Hospital
13.00 – 13.15
A simplified Human Platelet Antigen (HPA) genotyping method utilising Oxford Nanopore long-read sequencing
Tom Browne, NHS Blood and Transplant
13.15 – 14.15
Lunch
Session moderators: Alan Lazarus and Brian Curtis
14.15 – 14.45
FcRn: the ultimate solution
James Bussel, Pediatric Hematology-Oncology, Weill Cornell Medicine, New York
14.45 – 15.15
HIT: new developments in our understanding of the pathophysiology
Tamam Bakchoul, University Hospital and Faculty of Medicine, Tübingen
15.15 – 16.00
Abtracts (3 oral presentations):
15.15 – 15.30
Differential antibody-mediated activation of platelets versus neutrophils in heparin-induced thrombocytopenia
Romy Meier, Sanquin Research
15.30 – 15.45
Cerebral venous sinus thrombosis and thrombocytopenia after adenovirus infection due to heparin-independent anti-PF4 antibodies
Günalp Uzun, Institute for Clinical and Experimental Transfusion Medicine, UNiversity Hospital and Medical Faculty of Tuebingen, Tuebingen, Germany
15.45 – 16.00
Anti-platelet factor 4-induced procoagulant platelets are key mediators of thrombus formation in vaccine-induced thrombotic thrombocytopenia
Jan Zlamal, Insitute for Clinical and Experimental Transfusion Medicine Tübingen
16.00 – 16.30
Coffee/tea break
Session moderators: Rick Kapur and Leendert Porcelijn
16.30 – 17.00
Neutrophil extracellular traps: allies or enemies?
Kimberly Martinod, Department of cardiovascular sciences, KU Leuven
17.00 – 17.30
TTP: the long and winding road toward targeted therapies
Jan Voorberg, Department of cellular hemostasis, Sanquin Research, Amsterdam
17.45
Assemble to depart by bus to Country Estate Amerongen
18.30 – 23.00
Exclusive dinner party at Country Estate Amerongen
23.00
Departure in buses back to De Reehorst
Sunday 29 September
09.00 – 09.30
Coffee/tea
Session moderators: Petter Höglund and Masja de Haas
09.30 – 10.00
Drug induced neutropenia
Brian Curtis, Platelet and Neutrophil Immunology Laboratory, Versiti Blood Center of Wisconsin, Milwaukee
10.00 – 10.30
Tools to study megakaryocyte biology
Julia Tilburg, Department of molecular hematology, Sanquin, Amsterdam
10.30 – 11.00
Inherited platelet disorders: which omics?
Maartje van den Biggelaar, Laboratory of proteomics, Sanquin Research, Amsterdam
11.00 – 11.30
Coffee/tea break
11.30 – 12.00
IgG Fc receptors in platelet auto- and alloimmunity
Alan Lazarus, Laboratory medicine and pathobiology, University of Toronto, Canada
12.00 – 12.30
IgG glycosylation as sugar switches
Gestur Vidarsson, Department of Experimental Immunohematology, Sanquin Research, Amsterdam
Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University
12.30 – 13.00
Future collaborations
Masja de Haas and Rick Kapur
13.00 – 14.00
Lunch and Farewell
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