PROGRAM

Thursday 26 September

18.30 – 20.30

Dinner at De Reehorst for early arrivals

Friday 27 September

08.30 – 09.00

Registration & coffee/tea

09.00 – 09.15

Welcome
Masja de Haas, Leendert Porcelijn and Rick Kapur

Session moderators: James Bussel and Masja de Haas

09.15 – 09.45

FNAIT: is personalized care possible?
Joanne Verweij, Department of Gynecology and Obstetrics, Leiden UMC

09.45 – 10.20

FNAIT: Prophylaxis and tolerance induction from mouse to (wo)men
Maria Therese Ahlen, Department of Platelet Immunology, University Hospital of North Norway, Tromsø

10.20 – 10.45

FNAIT: Integrate the integrins: αVβ3 versus αIIbβ3
Coert Margadant, Institute of Biology, Leiden University

10.45 – 11.15

Coffee/tea break

11.15 – 11.45

FNAIT: place of the placenta
Heidi Tiller, Department of Gynecology and Obstetrics, University Hospital of North Norway, Tromsø. Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø

11.45 – 13.00

Abstracts (5 oral presentations):

11.45 – 12.00
Design of a Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of Nipocalimab in Pregnancies at Risk for Fetal and Neonatal Alloimmune Thrombocytopenia (FREESIA-1)
Heidi Tiller, Department of Gynecology and Obstetrics, University Hospital of North Norway,  Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø

12.00 – 12.15
Placenta-associated biomarkers and pregnancy outcome in HPA-1a alloimmunization – a prospective cohort study
Nora Hersoug Nedberg, UiT The Arctic University of Norway, Tromsø

12.15 – 12.30
Maternal anti-HPA-1a antibody levels and intracranial haemorrhage in Norwegian FNAIT cohorts
Siw Leiknes Ernstsen, Norwegian National Unit for Platelet Immunology, University Hospital of North Norway, Tromsø

12.30 – 12.45
Rallying the troops: A Delphi Consensus Study on Prenatal Screening and Management in Pregnancies at Risk for Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
Romy Pothof, Leiden University Medical Centre and Sanquin Diagnostics Services Amsterdam

12.45 – 13.00
Design of a Global, Retrospective Chart Review to Characterize the Clinical Course of Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FREESIA-2)
Rebecca Zaha, Janssen Research and Development, LLC

13.00 – 14.15

Lunch

13.30 – 14.15

Breakout Session:
UK NEQAS for H&I External Proficiency Testing for Platelet Services: Current Performance and Future Challenges

Session moderators: Brian Curtis and Leendert Porcelijn

14.15 – 14.45

TRALI: through the eyes of clinicians
Robert Klanderman, Department of Laboratory of Experimental Intensive Care and Anesthesiology, and Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam

14.45 – 15.15

TRALI: new insights into the immunopathology
Rick Kapur, Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam

15.15 – 16.00

Abstracts (3 oral presentations):

15.15 – 15.30
Anti-neutrophil Autoantibodies Are Associated With but Not Required for Triggering Macrophage Uptake of Neutrophils in Vitro by Autoimmune Neutropenia Plasmas
Peter Norris, Karolinska Institutet and Karolinska University Hospital

15.30 – 15.45
Presence of “ACKR1/DARC null” polymorphism in Arabs from Jisr az-Zarqa with benign ethnic neutropenia
Nechama Sharon, Laniado Hospital

15.45 – 16.00
Neonatal alloimmune neutropenia caused by anti-HNA-2 antibodies as a differential diagnosis to congenital neutropenia
Petter Höglund, Karolinska Institutet and Karolinska University Hospital

16.00 – 16.30

Coffee/tea break

Session moderators: Primoz Rozman and Rick Kapur

16.30 – 17.00

Extracellular vesicles: the methodological approach is key
Rienk Nieuwland, Amsterdam Vesicle Center, Amsterdam University Medical Centers

17.00 – 17.30

Extracellular vesicles: influencers of the immune system
Eric Boilard, Department of Microbiology and Immunology, Faculty of Medicine, Université Laval

17.30 – 18.30

Poster walk

18.30 – 21.00

Dinner at De Reehorst

Saturday 28 September

08.30 – 09.00

Coffee/tea

Session moderators: Maria Therese Ahlen and Rick Kapur

09.00 – 09.20

ITP: through the eyes of clinicians
Tanja Netelenbos, Department of Haematology, HagaZiekenhuis Den Haag

09.20 – 09.40

ITP:  autoantibody detection
Leendert Porcelijn, Sanquin Diagnostic Services, Amsterdam

09.40 – 10.10

ITP: targeted treatment; what are the current options?
A.J. Gerard Jansen, Department of Haematology, Erasmus Medical Center, Rotterdam

10.10 – 10.40

ITP: T-cells in the spleen
Sylvain Audia, Unit of Tumor-Graft-Versus-Host Interaction / Cellular and Gene Engineering, French Institute of Health and Medical Research

10.40 – 11.15

Coffee/tea break

11.15 – 13.15

Abstracts (8 oral presentations):

11.15 – 11.30
Cutaneous Hemorrhage Types as Supportive Factors for Predicting Chronic Immune Thrombocytopenia in Children
Nechama Sharon, Laniado Hospital

11.30 – 11.45
The ‘Stop TPO-receptor agonist in ITP Patients’ (STIP) study; a quest to unravel the immune modulating effects of romiplostim
Vivianne Nelson, Sanquin/ HagaZiekenhuis/ LUMC

11.45 – 12.00
Isolation and characterization of anti-HPA-1a monoclonal antibodies
Janita Oosterhoff, Sanquin

12.00 – 12.15
An Optimised Procedure for Luminex-based HPA-specific Antibody Screening and Identification (PakLx assay), with a Cost-effective Approach and Improved Sensitivity
Gerald Bertrand, BloodCenter of Brittany EFS

12.15 – 12.30
Performing fetal platelet genotyping on maternal plasma is not necessary in all indications. First retrospective study of French practices and neonate characteristics
Rachel Petermann, APHP – Saint Antoine Hospital

12.30 – 12.45
An accurate determination of HNA-2 with nanopore sequencing
Kirstine Kløve-Mogensen, Department of Clinical Immunology, Aalborg University Hospital

12.45 – 13.00
Autoantibody detection in childhood neutropenia. Do we
need test cells? To bead or not to bead, that is the question!
Paul Ratcliffe, Karolinska Institutet and Karolinska University Hospital

13.00 – 13.15
A simplified Human Platelet Antigen (HPA) genotyping method utilising Oxford Nanopore long-read sequencing
Tom Browne, NHS Blood and Transplant

13.15 – 14.15

Lunch

Session moderators: Alan Lazarus and Brian Curtis

14.15 – 14.45

FcRn: the ultimate solution
James Bussel, Pediatric Hematology-Oncology, Weill Cornell Medicine, New York

14.45 – 15.15

HIT: new developments in our understanding of the pathophysiology
Tamam Bakchoul, University Hospital and Faculty of Medicine, Tübingen

15.15 – 16.00

Abtracts (3 oral presentations):

15.15 – 15.30
Differential antibody-mediated activation of platelets versus neutrophils in heparin-induced thrombocytopenia
Romy Meier, Sanquin Research

15.30 – 15.45
Cerebral venous sinus thrombosis and thrombocytopenia after adenovirus infection due to heparin-independent anti-PF4 antibodies
Günalp Uzun, Institute for Clinical and Experimental Transfusion Medicine, UNiversity Hospital and Medical Faculty of Tuebingen, Tuebingen, Germany

15.45 – 16.00
Anti-platelet factor 4-induced procoagulant platelets are key mediators of thrombus formation in vaccine-induced thrombotic thrombocytopenia
Jan Zlamal, Insitute for Clinical and Experimental Transfusion Medicine Tübingen

16.00 – 16.30

Coffee/tea break

Session moderators: Rick Kapur and Leendert Porcelijn

16.30 – 17.00

Neutrophil extracellular traps: allies or enemies?
Kimberly Martinod, Department of cardiovascular sciences, KU Leuven

17.00 – 17.30

TTP: the long and winding road toward targeted therapies
Jan Voorberg, Department of cellular hemostasis, Sanquin Research, Amsterdam

17.45

Assemble to depart by bus to Country Estate Amerongen

18.30 – 23.00

Exclusive dinner party at Country Estate Amerongen

23.00

Departure in buses back to De Reehorst

Sunday 29 September

09.00 – 09.30

Coffee/tea

Session moderators: Petter Höglund and Masja de Haas

09.30 – 10.00

Drug induced neutropenia
Brian Curtis, Platelet and Neutrophil Immunology Laboratory, Versiti Blood Center of Wisconsin, Milwaukee

10.00 – 10.30

Tools to study megakaryocyte biology
Julia Tilburg, Department of molecular hematology, Sanquin, Amsterdam

10.30 – 11.00

Inherited platelet disorders: which omics?
Maartje van den Biggelaar, Laboratory of proteomics, Sanquin Research, Amsterdam

11.00 – 11.30

Coffee/tea break

11.30 – 12.00

IgG Fc receptors in platelet auto- and alloimmunity
Alan Lazarus, Laboratory medicine and pathobiology, University of Toronto, Canada

12.00 – 12.30

IgG glycosylation as sugar switches
Gestur Vidarsson, Department of Experimental Immunohematology, Sanquin Research, Amsterdam
Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University

12.30 – 13.00

Future collaborations
Masja de Haas and Rick Kapur

13.00 – 14.00

Lunch and Farewell

Sponsors